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MilliporeSigma™ Calbiochem™ Rapamycin

Rapamycin, CAS 53123-88-9, is an immunosuppressant that selectively inhibits mTOR and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM).

Manufacturer:  MilliporeSigma™ 55321010MG

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Catalog No. 55-321-010MG


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Description

Description

Anti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. A 5mm (500µg/109µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10mm (1mg/109µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
Specifications

Specifications

99% by HPLC
10mg
53123-88-9
914.2g/mol
Clear film
Mammalian target of rapamycin (mTOR)
C51H79NO13
DMSO or MeOH
Documents
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