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MilliporeSigma™ Calbiochem™ ASIC Channel Modulator II, GMQ
A positively charged guanidium-containing quinazoline that modulates ASIC function by blocking acid-induced maximal peak current as well as by altering ASICs pH dependence for activation and inactivation, enabling a partial, but sustained ASIC3 activation around neutral pH (4
Supplier: MilliporeSigma™ 5.00523.0001
Description
A positively charged guanidium-containing quinazoline that modulates ASIC function by blocking acid-induced maximal peak current as well as by altering ASICs pH dependence for activation and inactivation, enabling a partial, but sustained ASIC3 activation around neutral pH (4.4% of pH 5-induced peak current with 1mm GMQ at pH 7.4), which is inhibitable by Amiloride (Cat. No. 129876). Intraplantar paw injection (10μL 100μM) is reported to elicit a pain response in asic3+/+ , but not asic3-/- , mice in vivo . GMQ targeting area appears to overlap with Amiloride binding site in the pore region, but is distinct from ASIC calcium binding site.Specifications
| Protect from light | |
| Solid | |
| 99% by HPLC | |
| C10H11N5 |
| 25 mg | |
| White | |
| ASIC3 | |
| DMSO |
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