MilliporeSigma™ Calbiochem™ ATR Inhibitor III, ETP-46464

A cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC₅₀

Supplier:  MilliporeSigma™ 5.00508.0001

Catalog No. 50-050-80001

Description

A cell-permeable quinoline-containing heterotricyclic compound that acts as a potent inhibitor against mTOR, ATR, DNA-PK, PI 3-Kα, and ATM (IC₅₀ = 0.6, 14, 36, 170, and 545 nM, respectively) and preferentially suppresses radiation-induced cellular ATR activity (>90% at 500nM) over ATM or DNA-PK activity (IC₅₀ > 5μM) in U2OS cells, while exhibiting much reduced or little potency toward a panel of 26 other kinases (>55% inhibition at 5μM). Shown to synergize with UCN-01 (Cat. No. 539644) in replicative stress induction in S-phase replicating U2OS (1.5-, 61-, and 190-fold of control RS, respectively, with 1μM ETP-46464, 50nM UCN-01, or combined treatment).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Specifications

• Color: White
• Target Proteins: ATR
• Solubility: DMSO
• Form: Powder

• Description: 99% by HPLC
• Molecular Formula: C₃₀H₂₂N₄O₂
• Content And Storage: Protect from light
• Quantity: 10 mg