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EMD Millipore Calbiochem™ Bafilomycin A1, Streptomyces griseus Available on GSA/VA Contract for Federal Government customers only.

Bafilomycin A1, CAS 88899-55-2, acts as a highly potent and specific inhibitor of vacuolar-type H+-ATPase (Ki = 500 pM). Blocks the fusion of autophagosome with lysosome.

Manufacturer:  EMD Millipore 1960001SET

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Catalog No. 19-600-01SET

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A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution™ format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).
Description & Specifications


90% by HPLC
Protect from Light
vacuolar type H+ ATPase
White solid
1 set
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