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MilliporeSigma™ Calbiochem™ Cuspin-1

A cell-permeable pyridinylphenyl-methanone compound that is reported to effectively upregulate SMN (survival of motor neuron) protein level in 3 out of 4 SMA (spinal muscular atrophy) patient-derived fibroblast lines (by 71% to 93% increase in 48 h; 5µg/mL), but not HT1080, 293T, A549, two human ESC-MN lines, MEF, mESC-MN, rat PC12, or rat ST14A cells

Manufacturer:  MilliporeSigma™ 5.04906.0001

Catalog No. 50-490-60001


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Description

Description

A cell-permeable pyridinylphenyl-methanone compound that is reported to effectively upregulate SMN (survival of motor neuron) protein level in 3 out of 4 SMA (spinal muscular atrophy) patient-derived fibroblast lines (by 71% to 93% increase in 48 h; 5µg/mL), but not HT1080, 293T, A549, two human ESC-MN lines, MEF, mESC-MN, rat PC12, or rat ST14A cells. Shown to preferentially stimulate cellular Erk (Thr202/Tyr204) over Akt (Ser473) phosphorylation in SMA fibroblast line 9677 in a time-dependent manner (tmax = 24 h; 10µg/mL), indicative of Ras-Raf-MEK signaling pathway activation.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Specifications

Specifications

94% by HPLC
Protect from Light
Ras
DMSO
Brown powder
25mg
C13H10BrNO
Documents
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