Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ Calbiochem™ DNA Methyltransferase Inhibitor II, SGI-1027

A cell-permeable quinoline compound that is shown to inhibit human DNMT1 (IC50 = 6 and

Manufacturer:  MilliporeSigma™ 26092110MG

Catalog No. 26-092-110MG


Add to cart

Description

Description

A cell-permeable quinoline compound that is shown to inhibit human DNMT1 (IC50 = 6 and 12.5µM, respectively, with Hemimethylated DNA or Poly(dI-dC) as the substrate), murine DNMT3a and 3b (IC50 = 8 and 7.5µM, respectively, with Poly(dI-dC) as the substrate), as well as CpG DNA methylase M. Sss I (IC50 = 13.5 and 16µM, respectively, with Poly(dI-dC) as the substrate and 75 or 150nM AdoMet) of mycoplasma Spiroplasma sp. strain MQ1, presumably by competing with AdoMet (S-adenosyl-L-methionine , SAM) for the enzyme's cofactor binding site. Shown to be 2-, 3-, and 5-fold more effective than Decitabine (Cat. No. 189825), respectively, in reactivating p16 mRNA (2.5µM for 7 days), MLH1 mRNA (2.5µM for 7 days), and p16 protein expression (1.0 or 2.5µM for 12 days) in human colon carcinoma RKO cultures by reducing CpG island hypermethylation found in the promoter regions of TSGs (tumor suppressor genes) without inducing genome-wide hypomethylation or caspase-3 activation.
Specifications

Specifications

88% by HPLC
Protect from Light
C27H23N7O
DMSO
Pale yellow powder
10mg
461.5g/mol
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit