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MilliporeSigma™ Calbiochem™ DP2 Antagonist II

The (R) enantiomer of a cell-permeable alkynylphenoxyacetic acid that acts as a high affinity antagonist against the G protein-coupled PGD2

Manufacturer:  MilliporeSigma™ 3002662MG

Catalog No. 30-026-62MG


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Description

Description

The (R) enantiomer of a cell-permeable alkynylphenoxyacetic acid that acts as a high affinity antagonist against the G protein-coupled PGD2 (Cat. No. 538909) receptor CRTH2/DP2 ( K i = 5.3 and 5.0nM against human and murine DP2, respectively), exhibiting much reduced potency against a panel of more than 50 other receptors and ion channels. Effectively inhibits DP2-dependent chemotaxis of primary human eosinophils (IC50 = 100nM). Exhibits higher Caco-2 permeability than DP2 Antagonist I (Cat. No. 300264), but less oral bioavailability in mice.
Specifications

Specifications

93% by HPLC
Do Not Freeze
Protect from Light
DP2
451.23g/mol
White powder
2mg
C20H13Cl2FN2O5
DMSO
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