MilliporeSigma™ Calbiochem™ eIF2-GTP-tRNAiMet ternary complex Inhibitor, BTdCPU

Description

The eIF2-GTP-tRNA

A cell-permeable N, N'-diarylurea that acts as an inhibitor of the formation of the ternary complex of eukaryotic translation initiation factor 2 (eIF2), GTP and the initiator methionine tRNA (Met-tRNA_i), a key regulatory step of translation initiation. It directly activates heme-regulated inhibitor kinase (HRI), which then phosphorylates eIF2α in cells at 10μM and in cell-free extracts dose-dependently, and thereby prevents respective ternary complex formation without elevating oxidative stress. The sensitivities of various cancer cell lines to the anti-proliferative effects of this compound are shown to correlate with the expression of HRI. Furthermore, this compound displays tumor growth inhibition in a mice xenograft model of MCF-7 human breast cancer cells at 175mg/kg, in vivo .

Specifications

• Color: White
• Description: 99% by HPLC
• CAS: 1257423-87-2
• Molecular Formula: C₁₃H₈Cl₂N₄OS
• Formula Weight: 339.2g/mol
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 10 mg