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EMD Millipore Calbiochem™ G-Protein βγ Binding Peptide, mSIRK

A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange.

Manufacturer:  EMD Millipore 3718185MG

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Catalog No. 37-181-85MG


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Specifications

Description

A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Shown to cause a rapid activation of ERK1/2 (EC50 ~ 2.5 - 5µM) in rat arterial smooth muscle and Rat2 cells. Also promotes the phosphorylation of JNK and p38 MAP kinase, phospholipase C and causes Ca2+ release from internal stores. Negative control is also available (Cat. No. 371820).
Description & Specifications

Specifications

Supplied as a trifluoroacetate salt.
Lyophilized
5mg
C93H150N20O25
DMSO
95% by HPLC
Hygroscopic
N-myristoylated G-protein βγ selective binding
1948.3g/mol
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