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MilliporeSigma™ Calbiochem™ Gap Junction Enhancer, PQ7

Catalog No. 5062160001
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10mg

Description

A cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ∽500nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents

A cell-permeable quinoline derived compound with low toxicity that enhances gap junctional activity by about 16-fold (at ∽500nM) in T47D breast cancer cells and thereby potentiates the effect of chemotherapeutic agents. Blocks T47D cell colony formation (IC50 = 100nM) and reduce the growth of T47D xenograft tumors by 100% in Nu/Nu mice. Increases caspase-3, - 8, and -9 expression by 1.6, 2.8, and 3.8-fold, respectively to induce apoptotic cell death. Can work synergistically with cisplatin to reduce or totally eliminate tumor growth. Increases the expression of connexins 26, 32, and 43 to allow more efficient trafficking of cisplatin.
TRUSTED_SUSTAINABILITY

Specifications

Color Tan
Description 98% by HPLC
Molecular Formula C23H19F3N2O3
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
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