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MilliporeSigma™ Calbiochem™ HDAC Inhibitor XVII
A cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC50 = 27nM), displaying much reduced or little potency against HDAC1/3 (IC50
Supplier: MilliporeSigma™ 5.00671.0001
Description
A cell-permeable N-hydroxycinnamide derivative that acts a highly potent and HDAC8-selective histone deacetylase inhibitor (IC50 = 27nM), displaying much reduced or little potency against HDAC1/3 (IC50 = 3.0μM), HDAC2/4/6/10/11 (IC50 >20μM), or total HDAC activity in HeLa nuclear extract (IC50 >10μM). Reported to preferentially inhibit the proliferation of human lung cancer cells CL1-5, H1299, and A549 (IC50 from 7 to 8μM), while being much less toxic to normal human lung IMR-90 cells (73% inhibition at 40μM).Specifications
| Protect from light | |
| Powder | |
| 99% by HPLC | |
| C22H19NO3 | |
| DMSO |
| 10 mg | |
| Light Beige | |
| HDAC8 selective | |
| 345.39g/mol |
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