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MilliporeSigma™ Calbiochem™ Hhat Inhibitor, RU-SKI 43
A cell-permeable dihydrothienopyridinyl-ethanone compound that acts as an effective inhibitor against MBOAT family member Hhat/hedgehog acyltransferase-catalyzed ShhN palmitoylation in a palmitoyl CoA-noncompetitive ( K i = 6,9μM; [ShhN] = 38μM) and ShhN-uncompetitive ( K i
Supplier: MilliporeSigma™ 5.04521.0001
Description
A cell-permeable dihydrothienopyridinyl-ethanone compound that acts as an effective inhibitor against MBOAT family member Hhat/hedgehog acyltransferase-catalyzed ShhN palmitoylation in a palmitoyl CoA-noncompetitive ( K i = 6,9μM; [ShhN] = 38μM) and ShhN-uncompetitive ( K i = 7.4μM; [palmitoyCoA] = 30μM) manner. Effectively prevents Shh- & Hhat-transfected COS-1 cells from activating hedgehog signaling in co-cultured C3H10T1/2 cells (∽80% inhibition with10μM inhibitor) by inhibiting COS-1 intracellular ShhN palmitoylation (by 52% and 80%, respectively, with 10 or 20μM drug treatment) without affecting cellular palmitoylation of H-ras & fyn, myristoylation of c-Src & Wnt3a, Shh autoprosessing, or the protein level and localization of Shh & Hhat. Exhibits short plasma half-life in mice ( t 1/2 = 17 min; i.v.).
Specifications
| Off-white | |
| Hhat | |
| DMSO | |
| Semi-solid |
| 98% by HPLC | |
| C22H30N2O2S | |
| Protect from light | |
| 10 mg |
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