MilliporeSigma Calbiochem Indomethacin, 2 ft.-Trifluoromethyl
A cell-permeable, bioavailable 2 ft.-trifluoromethyl analog of Indomethacin ( Cat. No. 405268) t
Manufacturer: MilliporeSigma 5.04924.0001
DescriptionA cell-permeable, bioavailable 2 ft.-trifluoromethyl analog of Indomethacin ( Cat. No. 405268) that acts as a highly potent, time-dependent inhibitor of cyclooxygenase -2 (COX-2; IC50 = 267 and 388nM for mouse and human COX-2, respectively) and its several mutant forms. Does not affect COX-1 activity even at high concentrations (IC50 >100µM). Interacts with human COX-2 with much greater affinity than indomethacin (KI = 1.5 vs 13µM) and blocks COX-2 dependent arachidonic acid oxygenation (IC50 = 150nM in 1483 human head and neck squamous cell carcinoma cells). Further, minimizes swelling in carrageenan-induced rat paw edema model (EC50 = 1.7mg/kg, p.o.) with no gastrointestinal bleeding at higher doses (10mg/kg).
|98% by HPLC|
|Protect from Light|
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