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MilliporeSigma™ Calbiochem™ InSolution™ Olomoucine

A purine derivative that acts as a potent and selective inhibitor of p34cdc2/cyclin B (IC50 = 7µM) and related kinases, including p33cdk2/cyclin A (IC50 = 7µM), p33cdk2/cyclin E (IC50 = 7µM), p33cdk5/p35 (IC50 = 3µM), and p44MAPK (IC50 = 25µM)

Manufacturer:  MilliporeSigma™ 4956245MG

Catalog No. 49-562-45MG


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Description

Description

A purine derivative that acts as a potent and selective inhibitor of p34cdc2/cyclin B (IC50 = 7µM) and related kinases, including p33cdk2/cyclin A (IC50 = 7µM), p33cdk2/cyclin E (IC50 = 7µM), p33cdk5/p35 (IC50 = 3µM), and p44MAPK (IC50 = 25µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D1 (IC50 >1 mM) and p40cdk6/cyclin D3 (IC50 >250µM). Does not significantly affect the activity of other protein kinases even at 1mm concentrations. Known to inhibit DNA synthesis in interleukin-2 stimulated T lymphocytes and triggers G1 arrest similar to that observed in interleukin-2 deprived cells. Also used to synchronize cells in G1.
Specifications

Specifications

A 50 mM (5mg/336μl) solution of Olomoucine in DMSO.
Liquid
5mg
C15H18N6O
98% by HPLC
Hygroscopic
Protect from Light
p34cdk1/cyclin B
298.3g/mol
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