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MilliporeSigma Calbiochem InSolution Olomoucine
A purine derivative that acts as a potent and selective inhibitor of p34cdc2/cyclin B (IC50 = 7µM) and related kinases, including p33cdk2/cyclin A (IC50 = 7µM), p33cdk2/cyclin E (IC50 = 7µM), p33cdk5/p35 (IC50 = 3µM), and p44MAPK (IC50 = 25µM)
Manufacturer: MilliporeSigma 4956245MG
Description
A purine derivative that acts as a potent and selective inhibitor of p34cdc2/cyclin B (IC50 = 7µM) and related kinases, including p33cdk2/cyclin A (IC50 = 7µM), p33cdk2/cyclin E (IC50 = 7µM), p33cdk5/p35 (IC50 = 3µM), and p44MAPK (IC50 = 25µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D1 (IC50 >1 mM) and p40cdk6/cyclin D3 (IC50 >250µM). Does not significantly affect the activity of other protein kinases even at 1mm concentrations. Known to inhibit DNA synthesis in interleukin-2 stimulated T lymphocytes and triggers G1 arrest similar to that observed in interleukin-2 deprived cells. Also used to synchronize cells in G1.Specifications
A 50 mM (5mg/336μl) solution of Olomoucine in DMSO. | |
Liquid | |
5mg | |
C15H18N6O |
98% by HPLC | |
Hygroscopic Protect from Light |
|
p34cdk1/cyclin B | |
298.3g/mol |
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