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EMD Millipore Calbiochem™ Lactacystin, Synthetic Available on GSA/VA Contract for Federal Government customers only.

Lactacystin, Synthetic, CAS 1258004-00-0, is an irreversible inhibitor of 20S proteasome inhibitor (IC50 = 500 nM). A covalent inhibitor of the chymotrypsin & trypsin-like activities of proteasome.

Manufacturer:  EMD Millipore 426100200UG

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Catalog No. 42-610-0200UG


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Specifications

Description

An irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC50 = 500nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin- and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells and inhibits progression of synchronized Neuro 2A cells and MG-63 human osteosarcoma cells beyond the G1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10µM).
Description & Specifications

Specifications

99% by HPLC
200μg
1258004-00-0
376.4g/mol
White solid
20S proteasome (MCP; multicatalytic proteinase complex)
C15H24N2O7S
DMSO or H2O
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