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MilliporeSigma™ Calbiochem™ Lactacystin, Synthetic
Lactacystin, Synthetic, CAS 1258004-00-0, is an irreversible inhibitor of 20S proteasome inhibitor (IC50 = 500 nM). A covalent inhibitor of the chymotrypsin & trypsin-like activities of proteasome.
Supplier: MilliporeSigma™ 4261001MG
Description
An irreversible proteasome inhibitor. A Streptomyces metabolite that acts as a highly specific inhibitor of the 20S proteasome (MCP; multicatalytic proteinase complex) (IC50 = 500nM for 20S proteasome). Blocks proteasome activity by targeting the catalytic β-subunit. Acts as a covalent inhibitor of the chymotrypsin- and trypsin-like activities of the proteasome. Induces neurite outgrowth in Neuro 2A mouse neuroblastoma cells and inhibits progression of synchronized Neuro 2A cells and MG-63 human osteosarcoma cells beyond the G1 phase of the cell cycle. Reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-κB activation (IC50 = 10μM).Specifications
| White | |
| 20S proteasome (MCP; multicatalytic proteinase complex) | |
| C15H24N2O7S | |
| DMSO or H2O | |
| 1 mg |
| 99% by HPLC | |
| 1258004-00-0 | |
| 376.4g/mol | |
| Solid |
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