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MilliporeSigma™ Calbiochem™ Microcystin-LR, Microcystis aeruginosa

Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa.

Supplier:  MilliporeSigma™ 475815500UG

Catalog No. 47-581-5500UG

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

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Description

Description

Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa . Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7 nM) and PP2A (IC50 = 40 pM). Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions. Has no effect on protein kinases, making it useful for reducing the effect of contaminating phosphatase activities in protein kinase assays. A 2.5mm (250μg/100μl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475821) in DMSO is also available.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Pale Yellow
PP1
C49H74N10O12
DMSO or MeOH
500 μg
95% by HPLC
101043-37-2
995.2g/mol
Lyophilized
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