MilliporeSigma Calbiochem Microcystin-LR, Microcystis aeruginosa
Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa.
Manufacturer: MilliporeSigma 475815500UG
DescriptionCyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa . Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7 nM) and PP2A (IC50 = 40 pM). Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions. Has no effect on protein kinases, making it useful for reducing the effect of contaminating phosphatase activities in protein kinase assays. A 2.5mm (250µg/100µl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475821) in DMSO is also available.
|95% by HPLC|
|Lyophilized pale-yellow solid|
|DMSO or MeOH|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok