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MilliporeSigma™ Calbiochem™ Microcystin-LR, Microcystis aeruginosa

Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa.

Manufacturer:  MilliporeSigma™ 475815500UG

Catalog No. 47-581-5500UG


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Description

Description

Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa . Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7 nM) and PP2A (IC50 = 40 pM). Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions. Has no effect on protein kinases, making it useful for reducing the effect of contaminating phosphatase activities in protein kinase assays. A 2.5mm (250µg/100µl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475821) in DMSO is also available.
Specifications

Specifications

95% by HPLC
500μg
101043-37-2
995.2g/mol
Lyophilized pale-yellow solid
PP1
C49H74N10O12
DMSO or MeOH
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