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MilliporeSigma Calbiochem Microcystin-LR, Microcystis aeruginosa
Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa.
Manufacturer: MilliporeSigma 475815500UG
Description
Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria Microcystis aeruginosa . Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7 nM) and PP2A (IC50 = 40 pM). Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions. Has no effect on protein kinases, making it useful for reducing the effect of contaminating phosphatase activities in protein kinase assays. A 2.5mm (250µg/100µl) solution of Microcystin-LR, Microcystis aeruginosa (Cat. No. 475821) in DMSO is also available.Specifications
95% by HPLC | |
500μg | |
101043-37-2 | |
995.2g/mol |
Lyophilized pale-yellow solid | |
PP1 | |
C49H74N10O12 | |
DMSO or MeOH |
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