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MilliporeSigma™ Calbiochem™ mitoNEET Inhibitor NL-1, Thiazolidinedione

The mitoNEET Inhibitor NL-1, Thiazolidinedione controls the biological activity of mitoNEET.

Manufacturer:  MilliporeSigma™ 47582510MG

Catalog No. 47-582-510MG

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A cell-permeable, thiazolidinedione (TZD) that acts as an inhibitor of MitoNEET (IC50 = 0.9µM) in competition with rosiglitazone and pioglitazone, in liver mitochondrial suspensions. In pharmacological studies, it was found to alter isolated mitochondrial complex I respiration with an IC50 of 2.4µM and inhibited State III respiration up to 45%. Furthermore, this compound (6-25µM) is shown to dose-dependently reduce lactate-dehydrogenase release in SH-SY5Y cultures, leading to a 40% decrease in rotenone-induced cell-death.


98% by HPLC
Yellow solid
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