MilliporeSigma Calbiochem mitoNEET Inhibitor NL-1, Thiazolidinedione
The mitoNEET Inhibitor NL-1, Thiazolidinedione controls the biological activity of mitoNEET.
Manufacturer: MilliporeSigma 47582510MG
DescriptionA cell-permeable, thiazolidinedione (TZD) that acts as an inhibitor of MitoNEET (IC50 = 0.9µM) in competition with rosiglitazone and pioglitazone, in liver mitochondrial suspensions. In pharmacological studies, it was found to alter isolated mitochondrial complex I respiration with an IC50 of 2.4µM and inhibited State III respiration up to 45%. Furthermore, this compound (6-25µM) is shown to dose-dependently reduce lactate-dehydrogenase release in SH-SY5Y cultures, leading to a 40% decrease in rotenone-induced cell-death.
|98% by HPLC|
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