EMD Millipore Calbiochem Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride
Inhibits trypsin-like serine proteinases.
Manufacturer: EMD Millipore 61638250MG
DescriptionInhibits trypsin-like serine proteinases. Irreversibly inactivates trypsin without affecting chymotrypsin. Prevents nitric oxide production by activated macrophages by interfering with transcription of the iNOS gene. Blocks cell-cell adhesion and binding of HIV-1 virus to the target cells. In macrophages, blocks nitric oxide synthase induced by interferon-γ and lipopolysaccharides (EC50 = 80µM). Prevents endonucleolysis accompanying apoptotic death of HL-60 leukemia cells and normal thymocytes.
|95% by elemental analysis|
|trypsin like proteases|
|Aqueous solutions (unstable above pH 6.0)|