Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

MilliporeSigma™ Calbiochem™ NMDA Receptor NR2BCT(1292-1304)-TAT

A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function

Manufacturer:  MilliporeSigma™ 4545852MG

Catalog No. 45-458-52MG


Add to cart

Description

Description

A 13-mer NMDA receptor 2B (NR2B) subunit carboxy terminal (1292-1304) derived peptide that specifically binds DAPK1 (death-associated protein kinase 1) in a reversible manner and antagonizes the activated DAPK1-NR2B interaction and the potentiation of NMDAR function with no effect on either the catalytic activity of DAPK1 or the NMDA receptor physiology. Blocks Ca2+ influx through extrasynaptic NMDA receptors (at 50µM) and the blood-brain-barrier permeable version, namely NR2BCT(1292-1304) attached to TAT(47-57) via a spacer (6-aminohexanoic acid) protects cortical neurons from NMDA receptor-mediated insults and reduces brain infarction and improve neurological functions in mice (10mg/kg, i.v.).
Specifications

Specifications

Supplied as a trifluoroacetate salt
White powder
2mg
3382g/mol
98% by HPLC
Hygroscopic
Protect from Light
C143H254N64O32
H2O
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit