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MilliporeSigma™ Calbiochem™ Oxytocin Receptor Antagonist, MSC1630296

A tertiary sulfonamide-based compound that acts as a high-affinity oxytocin (OT) receptor-selective antagonist ( K i = 650 and 670 pM in 125I-OVTA-competitive binding assays using human and rat OT-R, respectively), while displaying 65-, 245-, and 23,000-fold reduced affinity, respectively, toward human vassopressin receptors V1a, V2

Manufacturer:  MilliporeSigma™ 5001062MG

Catalog No. 50-010-62MG


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Description

Description

A tertiary sulfonamide-based compound that acts as a high-affinity oxytocin (OT) receptor-selective antagonist ( K i = 650 and 670 pM in 125I-OVTA-competitive binding assays using human and rat OT-R, respectively), while displaying 65-, 245-, and 23,000-fold reduced affinity, respectively, toward human vassopressin receptors V1a, V2, and V1b. Shown to effectively inhibit OT- (10nM) induced Ca2+ mobilization in hOT-R-expressing HEK293-EBNA cells (IC50 = 14nM) in vitro and OT-stimulated uterine contractions in rats (1.4 -10mg/kg p.o. or 30mg/kg p.o.) in vivo . Product is supplied as a fumarate salt for enhanced aqueous solubility (20 and 10mg/ml, respectively, in water and HBSS).
Specifications

Specifications

93% by HPLC
Protect from Light
Oxytocin receptor
741.2g/mol
Brown solid
2mg
C30H33ClN6O5S·C4H4O4
DMSO
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