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MilliporeSigma™ Calbiochem™ p38 MAP Kinase Inhibitor XI

A cell-permeable naphthyridine N-oxide compound that acts as a potent, reversible p38α MAP kinase inhibitor (IC50 = 68nM) and exhibits excellent selectivity among 54-kina

Manufacturer:  MilliporeSigma™ 50617310MG

Catalog No. 50-617-310MG


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Description

Description

A cell-permeable naphthyridine N-oxide compound that acts as a potent, reversible p38α MAP kinase inhibitor (IC50 = 68nM) and exhibits excellent selectivity among 54-kinases. It acts on the ATP-binding site plus an adjacent hydrophobic pocket. Exhibits desirable ADME (Absorption, Distribution, Metabolism, and Excretion) profile with good microsomal stability, low toxicity, and low reactivity towards cytochrome P450 isozymes. Shown to inhibit lipopolysaccharide-induced TNFα production in a dose-dependent manner (ED50 of 0.5mg/kg).
Specifications

Specifications

98% by HPLC
Hygroscopic
Protect from Light
C21H14F2N2O
DMSO
Light beige powder
10mg
348.4g/mol
SDS
Documents
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