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MilliporeSigma™ Calbiochem™ PI 3-K Inhibitor XVIII

An N-myristoylated cell-permeable PI 3-K p110β-derived Gβγ-binding peptide

Supplier:  MilliporeSigma™ 5.00499.0001

Catalog No. 50-049-90001

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An N-myristoylated cell-permeable PI 3-K p110β-derived Gβγ-binding peptide (aa 514-537 in p110β C2-helical linker region) that prevents Gβγ-, but not RTK-, mediated p100β activation both in cell-free assays (1μM) and in cultures (30μM in p110β/p85/Akt/Gβγ-transfected HEK 293E cells) without affecting basal p100β activity, p110β-Rab5 interaction, nor Gβγ-dependent activation of adenylyl cyclase or p101-p110γ dimer. The ATP-competitive p110β inhibitior TGX-221 (Cat. No. 528113) can be used in conjunction for studying Gβγ dependency of p110β-mediated cellular functions.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.


Hygroscopic, Protect from light
Supplied as a trifluoroacetate salt.
Gβγ subunit of G-proteins
10 mg
95% by HPLC


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