MilliporeSigma™ Calbiochem™ PI 3-K Inhibitor XVIII
An N-myristoylated cell-permeable PI 3-K p110β-derived Gβγ-binding peptide
Supplier: MilliporeSigma™ 5.00499.0001
DescriptionAn N-myristoylated cell-permeable PI 3-K p110β-derived Gβγ-binding peptide (aa 514-537 in p110β C2-helical linker region) that prevents Gβγ-, but not RTK-, mediated p100β activation both in cell-free assays (1μM) and in cultures (30μM in p110β/p85/Akt/Gβγ-transfected HEK 293E cells) without affecting basal p100β activity, p110β-Rab5 interaction, nor Gβγ-dependent activation of adenylyl cyclase or p101-p110γ dimer. The ATP-competitive p110β inhibitior TGX-221 (Cat. No. 528113) can be used in conjunction for studying Gβγ dependency of p110β-mediated cellular functions.
Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
|Hygroscopic, Protect from light|
|Supplied as a trifluoroacetate salt.|
|Gβγ subunit of G-proteins|
|95% by HPLC|
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