MilliporeSigma™ Calbiochem™ Survivin Inhibitor III, LLP-3

A cell-permeable, dihydropyridinone compound that selectively disrupts survivin-Ran interaction in cell-free binding assays (IC₅₀ &l

Supplier:  MilliporeSigma™ 5.00614.0001

Catalog No. 50-061-40001

Description

A cell-permeable, dihydropyridinone compound that selectively disrupts survivin-Ran interaction in cell-free binding assays (IC₅₀ <0.3μM) and in U87 glioma cells (by 55% in 24 h; 20μM) via direct binding at survivin protein-protein interaction interface, while exhibiting much reduced or little potency against survivin-Smac/DIABLO, survivin-survivin, or XIAP-Smac/DIABLO interaction. LLP-3 treatment abrogates neurosphere formation in GMB cultures (IC₅₀ ≤35μM) by selectively depleting CD133+ GSC population via apoptosis induction. TMZ (Cat. No. 500609), in comparison, enriches GMB GSC population by preferentially eradicating non-GSC population. LLP-3 is also efficacious in treating human GMB xenograft in mice in vivo (25mg/kg/day via i.p.).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Specifications

• Quantity: 10 mg
• Content And Storage: Protect from light
• Description: 99% by HPLC
• Molecular Formula: C₃₂H₂₃ClN₂O₄
• Solubility: DMSO

• Form: Solid
• Color: Yellow
• Target Proteins: survivin
• Formula Weight: 535g/mol