Calcium Channel beta-4 Mouse anti-Human, Mouse, Rat, Clone: S10-7, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA527712
DescriptionThis gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy and juvenile myoclonic epilepsy. Multiple transcript variants encoding different isoforms have been found for this gene.
|Calcium Channel beta-4|
|PBS with 50% glycerol and 0.09% sodium azide; pH 7.4|
|D4A055, O00305, Q8R0S4|
|CAB4, CACNLB4, EA5, EJM, Calcium channel voltage dependent beta 4 subunit|
|12298, 58942, 785|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot|
|Synthetic peptide amino acids 458-474 of rat CavB4|
|Human, Mouse, Rat|
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