Caldesmon, HMW Mouse anti-Human, Clone: SPM168, Abnova™
Mouse monoclonal antibody raised against native human Caldesmon, HMW.
Manufacturer: Abnova Corporation MAB13178
This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]
|Mouse monoclonal antibody raised against native human Caldesmon, HMW.|
|In 10mM PBS.|
|Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.
|Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)|
|Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (1-2 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL) The optimal working dilution should be determined by the end user.|
|Crude human uterus extract.|
|Protein A/G purification|
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