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Calpain 6 Mouse anti-Human, Clone: 1395CT446.22.5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524733

Catalog No. PIMA524733


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Description

Description

Calpains make up a ubiquitously expressed, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. Calpain 6 (CAPN6) is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin-like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.
Specifications

Specifications

Calpain 6
Monoclonal
0.65 mg/mL
PBS with 0.09% sodium azide
Q9Y6Q1
Calpain-6, Calpain-like protease X-linked, Calpamodulin, CalpM, CAPN6, CALPM, CANPX
Mouse
IgG1
400 μL
-20°C
Primary
827
Western Blot
1395CT446.22.5
Unconjugated
CAPN6
Liquid
CAPN6
human Calpain 6 recombit protein
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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