CAMLG Mouse anti-Human, Clone: OTI2H3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525893
DescriptionThe immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|CAML, calcium signal-modulating cyclophilin ligand, calcium-modulating cyclophilin ligand, calcium-signal modulating cyclophilin ligand, cyclophilin B-binding protein|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot|
|Full length human recombit protein of CAMLG produced in HEK293T cell|
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