Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

CANX/Calnexin Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS1693R

Catalog No. 50-198-4043


Add to cart

Description

Description

Calnexin, also referred to as IP90, p88 and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER). Many resident ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into multisubunit proteins. Studies indicate that calnexin associates with the major histocompatibility complex (MHC) class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes. It has been shown that calnexin is a chaperone that retains incompletely or improperly folded proteins in the ER. The sequence Lys-Asp-Glu-Leu (KDEL) or a closely related sequence, is present at the carboxy-terminus of soluble ER resident proteins such as GRP78 and GRP94 and protein disulfide isomerase. Integral membrane ER resident proteins, like calnexin, often lack this KDEL sequence but contain positively charged cytosolic residues that ensure ER retention. Calnexin contains a large ER luminal domain (461 amino acids), a transmembrane segment (22 amino acids), and a cytoplasmic tail (89 amino acids).
Specifications

Specifications

CANX/Calnexin
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
CANX
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
821
CANX
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
P27824
1110069N15Rik; AI988026; BOS_7035; calmegin; Calnexin; Canx; canx-a; canx-b; clgn; clnx; Cnx; D11Ertd153e; FLJ26570; IP90; Major histocompatibility complex class I antigen-binding protein p88; p88; p90; pp90; RCJMB04_2d15
KLH conjugated synthetic peptide derived from human CANX.
Protein A
RUO
Antibody
Polyclonal
Human
SDS
Documents
Provide Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit