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Calpain 7 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550205

Catalog No. PA550205


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Description

Description

The antibody detects endogenous levels of total CAPN7 protein.

Calpain proteinases are defined currently as papain-like neutral proteases that are calcium activated. Calpains 1 and 2 are composed of a large subunit, which is proteolytically active, and a small subunit (also called calpain-4), or enhancer protein, that is not proteolytically active. The other calpain proteins identified to date (calpain 5, 6, 8, 9, 10, 11, 12, 13, 14, 15) are not known to require a small subunit. Domains in the large subunit include the amino terminal domain-I, the proteinase domain-II, domain-III, and the EF-hand domain-IV (domain-T in calpains 5 & 6, domain-N for calpain-7). Calpain-7 domain-N does not have the standard calpain EF hand domain for binding calcium, making it unclear whether it is calcium regulated. In place of the EF hand calcium-binding domain IV, calpain-7 has a sequence most closely resembling domain-III, with unknown function. Calpain-7 is widely distributed, found in most tissues analyzed.
Specifications

Specifications

Calpain 7
Polyclonal
Unconjugated
CAPN7
Liquid
CAPN7
Fusion protein corresponding to residues near the C terminal of human calpain 7
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin)
1.7 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q9Y6W3, Q9R1S8
PALBH
Rabbit
IgG
100 μL
-20°C
Primary
12339, 23473
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