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Carbonic Anhydrase IX/CA9, Mouse anti-Human,Equine, Alexa Fluor 350, Clone: SPM314, Novus Biologicals™

Mouse Monoclonal Antibody

Manufacturer:  Novus Biologicals NBP234408AF350

Catalog No. NB005893


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Description

Description

Carbonic Anhydrase IX/CA9 Monoclonal specifically detects Carbonic Anhydrase IX/CA9 in Human, Equine samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.
Specifications

Specifications

Carbonic Anhydrase IX/CA9
SPM314
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
Purified, Conjugated
CA9
Microsomal fraction of human renal cortical tissue homogenate was used to develop this Carbonic Anhydrase IX/CA9 Antibody (SPM314).
Protein A or G purified
RUO
Store at 4°C in the dark.
Monoclonal
Human, Equine
Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Alexa Fluor 350
50mM Sodium Borate with 0.05% Sodium Azide
CAIX, CA-IX, Carbonate dehydratase IX, carbonic anhydrase 9, carbonic anhydrase IX, carbonic dehydratase, EC 4.2.1.1, G250, Membrane antigen MN, MN, P54/58N, PMW1, RCC-associated antigen G250, RCC-associated protein G250, Renal cell carcinoma-associated antigen G250
Mouse
IgG2b Kappa
0.1 mL
Cancer, HIF Target Genes, Hypoxia, Lipid and Metabolism, Metastasis, Renal Cell Carcinoma Cell Markers
Primary
Recognizes a glycoprotein of ∽200kDa, identified as carbonic anhydrase IX (CAIX/gp200). Its epitope resides in the carbohydrate domain of gp200. It shows no significant cross-reactivity with other carbohydrate determinants, such as the Lewis blood group antigens, epithelial membrane antigen, HMFG, and AB blood group antigens. In normal kidney, gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule, as well as focally along the luminal surface of Bowman's capsule adjoining the outgoing proximal tubule. Reportedly, gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas. This MAb may be useful in the investigations of carcinomas of proximal nephrogenic differentiation especially those showing tubular differentiation.
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