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CARD14 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550370

Catalog No. PA550370


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Description

Description

The antibody detects endogenous levels of total CARD14 / CARMA2 protein.

CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-Kappa-B activation. When expressed in cells, this protein activated NF-Kappa-B and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-Kappa-B activation and endoplasmic reticulum stress-induced cell death.
Specifications

Specifications

CARD14
Polyclonal
Unconjugated
CARD14
Liquid
CARD14
Fusion protein corresponding to a region derived from internal residues of human caspase recruitment domain family, member 14
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1.3 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q9BXL6
CARMA2
Rabbit
IgG
100 μL
-20°C
Primary
79092
Documents
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