CARD8 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA587414

Catalog No. PIPA587414

Description

Immunogen sequence: MEARDKQVLR SLRLELGAEV LVEGLVLQYL YQEGILTENH IQEINAQTTG LRKTMLLLDI LPSRGPKAFD TFLDSLQEFP WVREKLKKAR EEAMTDLPAG DRLTGIPSHI LNSSPSDRQI NQLAQRLGPE WEPMVLSLGL SQTDIYRCKA NHPHNVQSQV VEAFIRWRQR FGKQATFQSL HNGLRAVEVD PSLLLHMLE; Positive Samples: K-562, A673, ES-2; Cellular Location: Cytoplasm, Nucleus

Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis, and caspase-1 and its related proteins ICEBERG and pesudo-ICE. Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein, it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-kappa-B activation.

Specifications

• Antigen: CARD8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CARD8
• Gene Alias: Apoptotic protein NDPP1, CARD 8, CARD inhibitor of NF-kappaB-activating ligands, CARD8, CARDINAL, CARD-inhibitor of NF-kappa-B-activating ligand, caspase recruitment domain family member 8, caspase recruitment domain family, member 8, caspase recruitment domain-containing protein 8, DACAR, DAKAR, DKFZp779L0366, KI, KIAA0955, NDPP, NDPP1, TUCAN, Tumor up-regulated CARD-containing antagonist of CASP9, tumor up-regulated CARD-containing antagonist of caspase nine
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 22900
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.14 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene Accession No.: Q9Y2G2
• Gene Symbols: CARD8
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CARD8 (NP_0037961)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG