Invitrogen™ Cardiac Troponin C Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA580171

Catalog No. PIPA580171

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: Rat Skeletal Muscle Tissue. IHC: Rat Cardiac Muscle Tissue.

Troponin (Tn) is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments, and as a result of calcium-ion uptake by troponin-C, the elements of the muscle thin filament undergo a series of allosteric changes which allow the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension.

Specifications

• Antigen: Cardiac Troponin C
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tnnc1
• Gene Alias: AI874626; cardiac 3; cardiac troponin C; Cardiac troponin I; CMD1FF; CMD1Z; CMD2A; CMH13; CMH7; cTnC; cTnI; MGC116817; RCM1; slow twitch skeletal/cardiac muscle troponin C; Tn1; TnC; TN-C; Tncc; Tni; TNN I3; TNNC; TNNC 1; Tnnc1; TNNI3; troponin C type 1 (slow); troponin C, cardiac/slow skeletal; troponin C, slow skeletal and cardiac muscles; troponin C1, slow; troponin C1, slow skeletal and cardiac type; Troponin I; Troponin I cardiac; TroponinI
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21924, 290561, 7134
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
• Gene Accession No.: P19123, P63316
• Gene Symbols: Tnnc1
• Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human cardiac Troponin C (1-18aa MDDIYKAAVEQLTEEQKN).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov