Cardiac Troponin I Monoclonal Antibody (22B11), Invitrogen™
Mouse Monoclonal Antibody
Supplier: Thermo Scientific MA122701
MA1-22701 detects Cardiac Troponin 1 in Human and Porcine samples. MA1-22701 has been successfully used in ELISA and Western Blot procedures. MA1-22701 immunogen corresponds to Unphosphorylated form of cardiac troponin I (amino acid residues 20-24).Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
|Cardiac Troponin I|
|CMD2A, CMH7, MGC116817, RCM1, TNNC1, cTnI|
|4° C, do not freeze|
|ELISA, Western Blot|
|Unphosphorylated form of cardiac troponin I (amino acid residues 20-24)|
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