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Cardiac Troponin I Mouse anti-Human, Mouse, Rat, Clone: 1D5D6, Proteintech Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 663761IG

Catalog No. 50-114-2713


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Description

Description

This antibody is specific to cTnI, but not cross-react with skeletal TnI.

Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
Specifications

Specifications

Cardiac Troponin I
1D5D6
Unconjugated
TNNI3
Liquid
TNNI3
Cardiac Troponin I Fusion Protein Ag16758
Protein G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P19429, P23693, P48787
Cardiac troponin I, CMD2A, CMH7, cTnI, RCM1, TNNC1, TNNI3, troponin I type 3 (cardiac), Troponin I, cardiac muscle
Mouse
IgG1
150 μL
-20°C
Primary
21954, 29248, 7137
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