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CARF Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550320

Catalog No. PA550320


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Description

Description

The antibody detects endogenous levels of total CARF / ALS2CR8 protein.

CARF (calcium-response factor), also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, is a 725 amino acid nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thought to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regulated with ARF, an ADP-ribosylation factor, and, through this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellular development, response to DNA damage and the aging process, suggesting that CARF participates in various events throughout the cell.
Specifications

Specifications

CARF
Polyclonal
Unconjugated
CARF
Liquid
CARF
Fusion protein corresponding to residues near the C terminal of human calcium responsive transcription factor
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
1.2 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q8N187
ALS2CR8
Rabbit
IgG
100 μL
-20°C
Primary
79800
Documents
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