Tocris™ Cariporide

Selective NHE1 inhibitor; cardioprotective and antitumor

Manufacturer: Tocris™ 5358/10

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Catalog No. 53-581-0

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Disclaimers:

For Research Use Only


    Specifications

    Product Type Cariporide
    Inhibitors Cariporide
    Purity >99
    Molecular Weight 283.35
    Quantity 10mg

    Selective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000µM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro. Reduces cardiac arrhythmia in vivo. Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.

    • Chemical Name: N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
    • Formula: C12H17N3O3S
    • CAS Number: 159138-80-4
    • Solubility: Soluble to 100mM in DMSO
    • Purity: >99

  • Description & Specifications

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