Selective NHE1 inhibitor; cardioprotective and antitumor
Manufacturer: Tocris 5358/10
DescriptionSelective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000µM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro. Reduces cardiac arrhythmia in vivo. Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.
- Chemical Name: N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
- Formula: C12H17N3O3S
- CAS Number: 159138-80-4
- Solubility: Soluble to 100mM in DMSO
- Purity: >99
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