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CASP3 Mouse anti-Human, Clone: 31A1067 , Abnova™

Mouse monoclonal antibody raised against human CASP3.

Manufacturer:  Abnova Corporation MAB12542

Catalog No. 89-933-723


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Description

Description

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq]

Specifications

Specifications

CASP3
31A1067
Mouse monoclonal antibody raised against human CASP3.
In PBS (0.05% BSA, 0.05% sodium azide).
CPP32/CPP32B/SCA-1
Mouse
IgG
50 ug
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Monoclonal
Human
Immunohistochemistry (PFA fixed), Western Blot
Unconjugated
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (5 ug/mL) Western Blot (2-3 ug/mL) The optimal working dilution should be determined by the end user.
Liquid
CASP3
Recombinant protein corresponding to human CASP3.
Protein G purification
RUO
Primary
836
SDS
Documents
Product Certifications
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