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Thermo Scientific™ Lab Vision™ Caspase 9/LAP6 Ab-4, Rabbit Polyclonal Antibody

Obtain accurate, reproducible results in immunohistochemistry, western blotting, and immunoprecipitation experiments.

Manufacturer:  Thermo Scientific™ RB1205P1

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Catalog No. RB1205P1

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Obtain accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments with Thermo Scientific™ Caspase 9/LAP6 Ab-4, Rabbit Polyclonal Antibody. 

 

Activation of procaspase-9 by Apaf-1 in the cytochrome c/dATP-dependent pathway requires proteolytic cleavage to generate the mature caspase molecule. Deletion of the Apaf-1 WD-40 repeats makes Apaf-1 constitutively active and capable of processing procaspase-9 independent of cytochrome c and ATP. Apaf-1-mediated processing of procaspase-9 occurs at Asp-315 by an intrinsic autocatalytic activity of procaspase-9 itself. Apaf-1 can form oligomers and may facilitate procaspase-9 autoactivation by oligomerizing its precursor molecules. Once activated, caspase-9 can initiate a caspase cascade involving the downstream executioners caspase-3, -6, and -7.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Mouse, Rat, Cow and Sheep. Others not tested.

Epitope: aa 1-134

Immunogen: Recombinant protein encoding aa 1-134 of human caspase 9

Molecular Weight: 46-48 kDa

Positive Control: Jurkat cells, Tonsil

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting
  • Immunoprecipitation (Denatured verified)

Note:

USA: RUO; Int'l: RUO

Specifications

Specifications

Caspase 9/LAP6 Ab-4
Polyclonal
Unconjugated
Concentrated
Recombinant protein encoding aa 1-134 of human caspase 9
500μL
Apoptosis
Primary
Bovine, Human, Murine, Rat
Immunoprecipitation, Western Blot
1mg/mL
Purified Ab with BSA and Azide
Rabbit
IgG
RUO
Primary
Polyclonal
SDS
Documents
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