Thermo Scientific Lab Vision Caspase 9/LAP6 Ab-4, Rabbit Polyclonal Antibody
Obtain accurate, reproducible results in immunohistochemistry, western blotting, and immunoprecipitation experiments.
Manufacturer: Thermo Scientific RB1205P1
Obtain accurate, reproducible results in immunohistochemistry, western blotting and immunoprecipitation experiments with Thermo Scientific Caspase 9/LAP6 Ab-4, Rabbit Polyclonal Antibody.
Activation of procaspase-9 by Apaf-1 in the cytochrome c/dATP-dependent pathway requires proteolytic cleavage to generate the mature caspase molecule. Deletion of the Apaf-1 WD-40 repeats makes Apaf-1 constitutively active and capable of processing procaspase-9 independent of cytochrome c and ATP. Apaf-1-mediated processing of procaspase-9 occurs at Asp-315 by an intrinsic autocatalytic activity of procaspase-9 itself. Apaf-1 can form oligomers and may facilitate procaspase-9 autoactivation by oligomerizing its precursor molecules. Once activated, caspase-9 can initiate a caspase cascade involving the downstream executioners caspase-3, -6, and -7.
Host Species: Rabbit
Species Reactivity: Human, Mouse, Rat, Cow and Sheep. Others not tested.
Epitope: aa 1-134
Immunogen: Recombinant protein encoding aa 1-134 of human caspase 9
Molecular Weight: 46-48 kDa
Positive Control: Jurkat cells, Tonsil
Cellular Localization: Cytoplasmic
- Immunohistochemistry (Formalin/paraffin)
- Western Blotting
- Immunoprecipitation (Denatured verified)
USA: RUO; Int'l: RUO
|Caspase 9/LAP6 Ab-4|
|Recombinant protein encoding aa 1-134 of human caspase 9|
|Bovine, Human, Murine, Rat|
|Immunoprecipitation, Western Blot|
|Purified Ab with BSA and Azide|
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.Ok