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Cathepsin D Mouse anti-Human, Clone: 892CT11.1.1, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524728

Catalog No. PIMA524728

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Cathepsin D (CatD) is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins apoptosis and autophagy. Human CatD is synthesized on the endoplasmic reticulum as a pre-pro-enzyme. Preprocathepsin D (412aa) is cleaved and glycosylated to form an inactive procathepsin D (392aa) and then further cleaved to generate an active intermediate (348aa) single-chain molecule. The active intermediate is further processed into mature two chain form of cathepsin D, this processing step is carried out by cathepsin B or L. The two-chain form consists of an amino terminal light chain and a carboxyl-terminal heavy chain. Additionally, several more amino acids are removed from the carboxyl terminus of the heavy chain. Procathepsin D (pCD), secreted from cancer cells, acts as a mitogen on both cancer and stromal cells and stimulates their proinvasive and pro-metastatic properties.
Specifications

Specifications

Cathepsin D
Monoclonal
0.4 mg/mL
PBS with 0.09% sodium azide
P07339
Cathepsin D, Cathepsin D light chain, Cathepsin D heavy chain, CTSD, CPSD
Mouse
IgG1
400 μL
-20°C
Primary
1509
Immunohistochemistry (Paraffin), Western Blot
892CT11.1.1
Unconjugated
CTSD
Liquid
CTSD
Purified His-tagged CTSD protein
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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