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Cathepsin L Mouse anti-Human, Clone: 33/1, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen BMS166

Catalog No. 50-112-5243


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Description

Description

Description: Cathepsin L is a lysosomal cysteine proteinase consisting of a heavy chain of about 25 kDa and a light chain of about 5 kDa derived proteolytically from the same precursor. Cathepsin L has been shown to be produced by many different cell types. Since cathepsin L is capable of degrading protein constituents of the extracellular matrix it is assumed to play a crucial role in tumor progression and metastasis and a number of other disorders where the destruction of the extracellular matrix is the major cause of disease (e.g. rheumatoid arthritis, neurodegeneration). Applications Tested: ELISA, Western Blotting. Purity: >95%.

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.
Specifications

Specifications

Cathepsin L
Monoclonal
0.1 mg/mL
PBS with no preservative; pH 7.2-7.4
P07711
1190035F06Rik, Ctsl1, MEP, fs, nkt
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ELISA, Western Blot
33/1
Unconjugated
CTSL
Liquid
CTSL
IgG1
100 μg
4° C
Primary
1514
Documents
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