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CATSPER1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA548491

Catalog No. PA548491


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Description

Description

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Specifications

Specifications

CATSPER1
Polyclonal
PBS with 0.09% sodium azide
Q8NEC5
Cation channel sperm-associated protein 1, CatSper1, hCatSper, CATSPER1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
117144
Western Blot
Unconjugated
CATSPER1
Liquid
CATSPER1
KLH conjugated synthetic peptide between 36-65 amino acids from the N-terminal region of human CATSPER1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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