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CATSPER1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550372

Catalog No. PA550372


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Description

Description

The antibody detects endogenous levels of total CATSPER1 protein.

Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
Specifications

Specifications

CATSPER1
Polyclonal
Unconjugated
CATSPER1
Liquid
CATSPER1
Fusion protein corresponding to residues near the C terminal of human cation channel, sperm associated 1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin)
1.8 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q8NEC5
SPGF7, CATSPER
Rabbit
IgG
100 μL
-20°C
Primary
117144
Documents
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