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CATSPER3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550374

Catalog No. PA550374


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Description

Description

The antibody detects endogenous levels of total CATSPER3 protein.

CatSpers (cation channel, sperm associated proteins) are ion transport proteins located on the surface of sperm cells in the principal piece of the sperm tail. CatSpers are vital to sperm motility, fertilization and cAMP-mediated calcium influx in sperm. There are four CatSper proteins in mammalian sperm, namely CatSper (or CatSper1), CatSper2, CatSper3 and CatSper4. CatSper proteins contain a single, six-transmembrane-spanning segment and exhibit the voltage-dependent Ca2+ channel four-repeat structure. CatSper proteins are believed to assemble into a heterotetrameric complex, forming an alkalinization-activated Ca2+-selective channel. Mutations in any of the genes encoding CatSper family proteins can result in male infertility. CatSper3 plays an important role in the hyperactivated motility of sperm cells, a process that is required in the preparation of sperm for fertilization.
Specifications

Specifications

CATSPER3
Polyclonal
Unconjugated
CATSPER3
Liquid
CATSPER3
Fusion protein corresponding to a region derived from internal residues of human cation channel, sperm associated 3
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1.3 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q86XQ3, Q80W99
CACRC
Rabbit
IgG
100 μL
-20°C
Primary
347732, 76856
Documents
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