CBLC Mouse anti-Human, Clone: OTI4E3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526045
DescriptionActs as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at ft.Tyr-419 ft.. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|CBL-3; RNF57; CBL-SL;|
|-20° C, Avoid Freeze/Thaw Cycles|
|Flow Cytometry, Western Blot|
|Human recombit protein fragment corresponding to amino acids 244-474 of CBLC produced in HEK293T cell|
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