Tocris CCG 1423
Induces intermediate mesoderm differentiation from ESCs; Rho/SRF pathway inhibitor
Manufacturer: Tocris 5233/10
DescriptionRho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid, LY 294002 and Pyridone 6, it induces intermediate mesoderm differentiation from ESCs.
- Chemical Name: N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)benzamide
- Formula: C18H13ClF6N2O3
- CAS Number: 285986-88-1
- Solubility: Soluble to 100mM in DMSO
- Purity: >99
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