Tocris™ CCG 203971

Inhibits the MRTF/SRF gene transcription pathway; antifibrotic agent

Manufacturer: Tocris™ 5277/50

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Catalog No. 52-775-0

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Disclaimers:

For Research Use Only


    Specifications

    Product Type CCG 203971
    Inhibitors CCG 203971
    Purity >98
    Molecular Weight 408.88
    Quantity 50mg

    Antifibrotic agent; inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway. Selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts. Inhibits expression of CTGF, α-SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGFβ-stimulated fibroblasts. Prevents bleomycin-induced skin thickening and collagen deposition in vivo. Also suppresses PC-3 cell migration in scratch wound assays (IC50 = 4.2µM).

    • Chemical Name: N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide
    • Formula: C23H21ClN2O3
    • CAS Number: 1443437-74-8
    • Solubility: Soluble to 50mM in DMSO
    • Purity: >98

  • Description & Specifications

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