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CCL7 (MCP-3) Mouse anti-Human, eFluor® 660, Clone: OLGMASCE, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen 50707741

Catalog No. 50-112-4432


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Description

Description

Description: This OLGMASCE monoclonal antibody reacts with human CCL7. CCL7, also known as MCP-3 (Monocyte Chemotactic Protein 3), is a member of the CC- subfamily of chemokines and is most closely related to CCL2 (MCP-1) and CCL8 (MCP-2). They are secreted by a variety of cell types in response to inflammatory stimuli and play critical roles in the recruitment of leukocytes to areas of inflammation. While all three MCP proteins are potent chemoattractants of monocytes and T cells, CCL7 appears to have the broadest range of activity, as it has also been demonstrated to attract activated NK cells, eosinophils, basophils, and neutrophils. CCL7 signals via the g protein-coupled receptors CCR1 and CCR2, both of which are shared with other CC-chemokines. Applications Reported: This OLGMASCE antibody has been reported for use in intracellular staining followed by flow cytometric analysis. Applications Tested: This OLGMASCE antibody has been pre-titrated and tested by intracellular staining followed by flow cytometric analysis of stimulated normal human peripheral blood cells using the Intracellular Fixation and Permeabilization Buffer Set (cat. 88-8824) and protocol. This can be used at 5 µL (0.06 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome. Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser. Filtration: 0.2 µm post-manufacturing filtered. This is a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix.
Specifications

Specifications

CCL7 (MCP-3)
Monoclonal
5 μL/Test
PBS with 0.1% gelatin, 0.2% BSA and 0.09% sodium azide; pH 7.2
P80098
FIC, MARC, MCP-3, MCP3, MGC138463, MGC138465, NC28, SCYA6, SCYA7
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry
OLGMASCE
eFluor™ 660
CCL7
Liquid
CCL7
IgG1, kappa
25 Tests
4° C, store in dark, DO NOT FREEZE!
Primary
6354
Documents
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