CCM2 Mouse anti-Human, Clone: OTI2E4, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525668
DescriptionThis gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|CCM2; cerebral cavernous malformation 2 ; C7orf22; MGC4067; MGC4607; MGC74868; PP10187|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of CCM2 produced in HEK293T cell|
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